The HEMOPATCH hemostatic sealant consists of a soft, thin, pliable, and flexible patch of bovine skin-derived collagen coated with NHS-PEG (pentaerythritol polyethylene glycol ether tetrasuccinimidyl glutarate). Due to its flexible structure, the application of HEMOPATCH to the desired hemostasis/sealing site is easily controlled. The uncoated side is marked with blue squares using a biocompatible dye to differentiate it from the coated side.